Trending in Longevity
- Rapamycin longevity dose: what physicians are actually prescribing
- Biological age testing: which clock is most accurate in 2026?
- NMN vs NR: updated comparison after new human trial data
Latest From Sources
- › Cellular reprogramming startup raises $200M in Series B
- › New epigenetic test claims accuracy to within 1.2 biological years
- › Senolytics enter phase 3 clinical trials for frailty
- › Mitochondrial transplantation shows promise in aging muscle tissue
- › UNITY Biotechnology updates on UBX1325 trial results
Cellular Rejuvenation & Telomere Science
Cellular rejuvenation may greatly extend how long we live
Researchers have identified a class of proteins that appear to reset cellular age markers, potentially adding decades to healthy lifespan. The implications for human trials are significant.
Researchers have identified a class of proteins that appear to reset cellular age markers, potentially adding decades to healthy lifespan. The implications for human trials are significant.
Vitamin D slows aging, increases telomere length
A large randomized trial finds that high-dose vitamin D supplementation measurably slows telomere shortening — one of the most reliable biological clocks we have.
A large randomized trial finds that high-dose vitamin D supplementation measurably slows telomere shortening — one of the most reliable biological clocks we have.
Scientists discover fountain of youth protein
A previously overlooked protein has been found to reverse several hallmarks of aging in mouse models. Human trials are expected within two years.
A previously overlooked protein has been found to reverse several hallmarks of aging in mouse models. Human trials are expected within two years.
New discovery in quest to slow aging
MIT researchers report a mechanism that governs how quickly cells accumulate damage over time — and more importantly, how to slow it down.
MIT researchers report a mechanism that governs how quickly cells accumulate damage over time — and more importantly, how to slow it down.
Metabolic Health & Dietary Longevity
Compound in coffee and chocolate slows down aging
Theobromide and related compounds found in cacao and coffee have been shown to activate AMPK pathways linked to longevity. Your morning routine may be doing more than you think.
Theobromide and related compounds found in cacao and coffee have been shown to activate AMPK pathways linked to longevity. Your morning routine may be doing more than you think.
Multivitamin slows down aging according to new clinical study
A three-year study of 3,500 adults finds daily multivitamin users show meaningfully slower biological aging on epigenetic clocks compared to placebo groups.
A three-year study of 3,500 adults finds daily multivitamin users show meaningfully slower biological aging on epigenetic clocks compared to placebo groups.
The day food noise died: The rise of cellular metabolism modulation
GLP-1 agonists are reshaping how we think about hunger, metabolism, and longevity. This deep dive covers the mechanisms and what they mean for healthspan.
GLP-1 agonists are reshaping how we think about hunger, metabolism, and longevity. This deep dive covers the mechanisms and what they mean for healthspan.
How long you've been overweight determines how fast your brain will decline
Duration of obesity — not just current weight — is the key predictor of cognitive decline speed, according to a 20-year longitudinal study. Timing your intervention matters.
Duration of obesity — not just current weight — is the key predictor of cognitive decline speed, according to a 20-year longitudinal study. Timing your intervention matters.
Emerging Immunotherapy & Cancer Disruptors
New immunotherapy drug is holy grail for cancer patients with dMMR tumors
A targeted immunotherapy shows near-complete remission in patients with mismatch repair deficient tumors across multiple cancer types — a potential paradigm shift in oncology.
A targeted immunotherapy shows near-complete remission in patients with mismatch repair deficient tumors across multiple cancer types — a potential paradigm shift in oncology.
Bacteria eats cancer tumors from within during breakthrough clinical trial
Engineered bacteria injected directly into solid tumors are showing remarkable ability to colonize and destroy cancer tissue from the inside, with minimal systemic side effects.
Engineered bacteria injected directly into solid tumors are showing remarkable ability to colonize and destroy cancer tissue from the inside, with minimal systemic side effects.
New light therapy successfully targets and kills cancer cells
Photodynamic therapy using a new class of photosensitizers achieves selective cancer cell destruction without damaging surrounding healthy tissue in early human trials.
Photodynamic therapy using a new class of photosensitizers achieves selective cancer cell destruction without damaging surrounding healthy tissue in early human trials.
Scientists discover natural compound that stops aggressive cancer growth
A compound derived from a common plant has been found to halt tumor progression in aggressive cancers by disrupting a key metabolic pathway cancer cells depend on.
A compound derived from a common plant has been found to halt tumor progression in aggressive cancers by disrupting a key metabolic pathway cancer cells depend on.
Biohacking Protocols
Cold exposure and brown fat activation: what the latest research shows
Cold plunging activates brown adipose tissue in ways that go beyond calorie burning — new research links it to improved insulin sensitivity and reduced inflammatory markers.
Cold plunging activates brown adipose tissue in ways that go beyond calorie burning — new research links it to improved insulin sensitivity and reduced inflammatory markers.
Red light therapy panel protocols for healthspan extension
A systematic review of red light therapy trials finds consistent benefits for mitochondrial function, skin aging markers, and muscle recovery at specific wavelengths and durations.
A systematic review of red light therapy trials finds consistent benefits for mitochondrial function, skin aging markers, and muscle recovery at specific wavelengths and durations.
HRV tracking as a longevity biomarker: current evidence
Heart rate variability is emerging as one of the most accessible and predictive biomarkers for biological age. Here's what your wearable data actually means.
Heart rate variability is emerging as one of the most accessible and predictive biomarkers for biological age. Here's what your wearable data actually means.
Sleep optimization and its impact on biological aging
Chronic sleep disruption accelerates epigenetic aging by up to three years. This review covers the mechanisms and the most evidence-backed interventions.
Chronic sleep disruption accelerates epigenetic aging by up to three years. This review covers the mechanisms and the most evidence-backed interventions.
Supplements & Compounds
NMN supplementation in humans: updated clinical data
New human trials of NMN confirm measurable improvements in NAD+ levels and some muscle function markers in older adults, though longevity effects remain to be established.
New human trials of NMN confirm measurable improvements in NAD+ levels and some muscle function markers in older adults, though longevity effects remain to be established.
Rapamycin for longevity: risks, benefits and current protocols
The mTOR inhibitor rapamycin remains the most validated longevity drug in animal models. This review covers what physicians prescribing it off-label are actually seeing.
The mTOR inhibitor rapamycin remains the most validated longevity drug in animal models. This review covers what physicians prescribing it off-label are actually seeing.
Quercetin and fisetin as senolytics: what the science actually says
Senolytic compounds that clear zombie cells have generated enormous excitement. Here's an honest assessment of the human evidence versus the mouse model hype.
Senolytic compounds that clear zombie cells have generated enormous excitement. Here's an honest assessment of the human evidence versus the mouse model hype.
Peptide therapeutics and their role in biological age reversal
BPC-157, TB-500, and related peptides are gaining traction in longevity circles. A researcher breaks down the mechanisms, the evidence quality, and the unknowns.
BPC-157, TB-500, and related peptides are gaining traction in longevity circles. A researcher breaks down the mechanisms, the evidence quality, and the unknowns.
Experts & Voices
Peter Attia on the four pillars of longevity medicine
Attia lays out his framework: exercise, nutrition, sleep, and emotional health — and why most people are optimizing in the wrong order for longevity.
Attia lays out his framework: exercise, nutrition, sleep, and emotional health — and why most people are optimizing in the wrong order for longevity.
David Sinclair's latest update on his personal longevity protocol
Sinclair updates his supplement stack and lifestyle protocol, discusses his latest lab findings, and addresses critics of the NAD+ and resveratrol research.
Sinclair updates his supplement stack and lifestyle protocol, discusses his latest lab findings, and addresses critics of the NAD+ and resveratrol research.
Rhonda Patrick on sulforaphane and aging
Patrick dives deep into sulforaphane's role in activating Nrf2 pathways and what that means for inflammation, brain aging, and cancer prevention.
Patrick dives deep into sulforaphane's role in activating Nrf2 pathways and what that means for inflammation, brain aging, and cancer prevention.
Bryan Johnson Blueprint: latest results and what changed
Johnson publishes his latest biological age measurements and protocol updates. Whether you find it inspiring or excessive, the data is genuinely interesting.
Johnson publishes his latest biological age measurements and protocol updates. Whether you find it inspiring or excessive, the data is genuinely interesting.